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|Title:||The pattern of bilirubin response to phototherapy for neonatal hyperbilirubinaemia|
|Citation:||Tan, K.L. (1982). The pattern of bilirubin response to phototherapy for neonatal hyperbilirubinaemia. Pediatric Research 16 (8) : 670-674. ScholarBank@NUS Repository.|
|Abstract:||The pattern of bilirubin response to phototherapy was studied using lamps with an emission spectrum closely similar to the bilirubin absorption spectrum. A dose-response relationship was demonstrated, with increased intensity of phototherapy resulting in greater response; however, the rate of bilirubin decline progressively decreased with increasing radiance till a 'saturation' point was reached, beyond which no further response occurred with further increase in radiance, suggesting a curvilinear relationship of the nature of an asymptotic regression. At the 'saturation' point, a 24-h decline of about 50% was achieved. With extended periods of phototherapy, a gradually decreasing response to phototherapy with declining bilirubin levels was observed, with maximal or moderate intensity phototherapy; an exponential regression was suggested. At about 5 mg/dl little further decline was observed with continued phototherapy. The rate of the 24-h decline evaluated at 6-h intervals was observed to be proportional to the bilirubin level at start of the 24-h period.|
|Source Title:||Pediatric Research|
|Appears in Collections:||Staff Publications|
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