Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133722
Title: Randomised controlled trial of methyldopa and isradipine in preeclampsia - Effects on uteroplacental and fetal hemodynamics
Authors: Montan, S.
Anandakumar, C. 
Arulkumaran, S. 
Ingemarsson, I.
Ratnam, S.S. 
Keywords: Doppler ultrasound
Fetal heart
Hypertension
Isradipine
Methyldopa
Issue Date: 1996
Citation: Montan, S., Anandakumar, C., Arulkumaran, S., Ingemarsson, I., Ratnam, S.S. (1996). Randomised controlled trial of methyldopa and isradipine in preeclampsia - Effects on uteroplacental and fetal hemodynamics. Journal of Perinatal Medicine 24 (2) : 177-184. ScholarBank@NUS Repository.
Abstract: This is a prospective randomised controlled study in 21 women admitted with preeclampsia in the third trimester. The mean arterial blood pressure decreased by 11.1 mmHg (95% confidence interval -14.9 to -7.3 mmHg) in the methyldopa group, and by 9.3 mmHg (95% confidence interval -14.4 to -4.2 mmHg) in the isradipine group. The maternal heart rate decreased by 6.9 beats per min (95% confidence interval -11.6 to -2.2 bpm) during methyldopa treatment, and by 2.5 beats per min (95% confidence interval -9.2 to 4.3) during isradipine treatment. Pulsatility index in maternal and fetal vessels was not affected by either of the two drugs. The birth weight and placental weight and neonatal outcome were similar and uneventful. The hypotensive effect was similar for methyldopa and isradipine. Except reduced maternal heart rate on methyldopa, fetal and uteroplacental hemodynamics were not altered during treatment of preeclampsia with methyldopa or isradipine.
Source Title: Journal of Perinatal Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/133722
ISSN: 03005577
Appears in Collections:Staff Publications

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