Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133200
Title: Melatonin concentrations in human serum, ventricular and lumbar cerebrospinal fluids as an index of the secretory pathway of the pineal gland
Authors: Tan, C.H. 
Khoo, J.C.M.
Issue Date: 1981
Source: Tan, C.H., Khoo, J.C.M. (1981). Melatonin concentrations in human serum, ventricular and lumbar cerebrospinal fluids as an index of the secretory pathway of the pineal gland. Hormone Research 14 (4) : 224-233. ScholarBank@NUS Repository.
Abstract: Melatonin was extracted from human sera, ventricular and lumbar cerebrospinal fluids taken within an hour from 25 patients undergoing neurosurgical operations such as ventricular shunts and craniotomy. Using a radioimmunoassay procedure, it was possible to measure the melatonin concentrations in 3 groups of patients: (a) those with obstructive hydrocephalus, (b) those with communicating hydrocephalus, and (c) those with normal cerebrospinal fluid flow. It was demonstrated that melatonin levels were higher in sera compared with those in lumbar and ventricular cerebrospinal fluids thus supporting the view that melatonin is primarily secreted into the bloodstream.
Source Title: Hormone Research
URI: http://scholarbank.nus.edu.sg/handle/10635/133200
ISSN: 03010163
Appears in Collections:Staff Publications

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