Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF00054011
Title: Implications of intermediate filament protein phosphorylation
Authors: Ku, N.-O.
Liao, J.
Chou, C.-F. 
Omary, M.B.
Keywords: intermediate filaments
keratins
phosphorylation
Issue Date: 1996
Citation: Ku, N.-O., Liao, J., Chou, C.-F., Omary, M.B. (1996). Implications of intermediate filament protein phosphorylation. Cancer and Metastasis Reviews 15 (4) : 429-444. ScholarBank@NUS Repository. https://doi.org/10.1007/BF00054011
Abstract: Intermediate filament (IF) proteins, a large family of tissue specific proteins undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural heterogeneity and hence presumed tissue specific functions. Although the function of IF proteins remains poorly understood, several regulatory roles for IF protein phosphorylation have been identified or are emerging. Those roles include filament disassembly and reorganization, solubility, localization within specific cellular domains, association with other cytoplasmic or membrane associated proteins, protection against physiologic stress and mediation of tissue-specific functions. Understanding the mechanistic and functional aspects of IF protein phosphorylation is providing insights not only regarding the function of this modification, but also regarding the function of IF proteins.
Source Title: Cancer and Metastasis Reviews
URI: http://scholarbank.nus.edu.sg/handle/10635/133058
ISSN: 01677659
DOI: 10.1007/BF00054011
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

89
checked on Sep 19, 2018

WEB OF SCIENCETM
Citations

87
checked on Sep 5, 2018

Page view(s)

13
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.