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https://scholarbank.nus.edu.sg/handle/10635/132919
Title: | Human myoblast genome therapy | Authors: | Law, P.K. Law, D.M. Lu, P. Sim, E.K.W. Haider, K.H. Ye, L. Li, X. Vakhromeeva, M.N. Berishvili, I.I. Bockeria, L.A. Liew, C.-C. |
Keywords: | Heart regeneration Human genome therapy Myoblasts |
Issue Date: | Sep-2006 | Citation: | Law, P.K., Law, D.M., Lu, P., Sim, E.K.W., Haider, K.H., Ye, L., Li, X., Vakhromeeva, M.N., Berishvili, I.I., Bockeria, L.A., Liew, C.-C. (2006-09). Human myoblast genome therapy. Journal of Geriatric Cardiology 3 (3) : 135-151. ScholarBank@NUS Repository. | Abstract: | Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. Injection injury activates regeneration of host myofibers that fuse with the engrafted myoblasts, sharing their nuclei in a common gene pool of the syncytium. Thus, through nuclear transfer and complementation, the normal human genome can be transferred into muscles of patients with genetic disorders to achieve phenotype repair or disease prevention. Myoblasts are safe and efficient gene transfer vehicles endogenous to muscles that constitute 50% of body weight. Results of over 280 HMGT procedures on Duchenne Muscular Dystrophy (DMD) subjects in the past 15 years demonstrated absolute safety. Myoblast-injected DMD muscles showed improved histology. Strength increase at 18 months post-operatively averaged 123%. In another application of HMGT on ischemic cardiomyopathy, the first human myoblast transfer into porcine myocardium revealed that it was safe and effective. Clinical trials on approximately 220 severe cardiomyopathy patients in 15 countries showed a | Source Title: | Journal of Geriatric Cardiology | URI: | http://scholarbank.nus.edu.sg/handle/10635/132919 | ISSN: | 16715411 |
Appears in Collections: | Staff Publications |
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