Please use this identifier to cite or link to this item: https://doi.org/10.1097/MBP.0b013e32831e30bd
Title: Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' Trial
Authors: Sare, G.M.
Gray, L.J.
Wardlaw, J.
Chen, C. 
Bath, P.M.W.
Keywords: Acute ischaemic stroke
Carotid stenosis
Cerebral blood flow
Clinical trial
Issue Date: Feb-2009
Citation: Sare, G.M., Gray, L.J., Wardlaw, J., Chen, C., Bath, P.M.W. (2009-02). Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' Trial. Blood Pressure Monitoring 14 (1) : 20-25. ScholarBank@NUS Repository. https://doi.org/10.1097/MBP.0b013e32831e30bd
Abstract: Background High blood pressure (BP) in acute stroke patients is both common and associated with a poor outcome, although best management remains unclear. Particular uncertainty exists in patients with carotid stenosis in whom lowering BP might reduce cerebral perfusion and worsen outcome. Methods Efficacy of Nitric Oxide in Stroke (ENOS) is an international, randomized controlled trial investigating the effect of lowering BP with glyceryl trinitrate in 5000 patients with acute stroke. This analysis is based on patients with ischaemic stroke for whom information on the carotid status was available. Neurological impairment (Scandinavian Stroke Scale) and rate of recurrent stroke were assessed on day 7, and the functional outcome (modified Rankin score) was determined on day 90. ENOS is ongoing, therefore analyses are blinded to treatment. Results At the time of analysis, 565 patients with ischaemic stroke had been randomized into ENOS and data on carotid status were available in 394 (70%) of these patients. Ipsilateral stenosis ≥ 50% was present in 50 patients (13%). Six of 344 (2%, 95% confidence interval: 0.7, 4%) patients with ipsilateral stenosis
Source Title: Blood Pressure Monitoring
URI: http://scholarbank.nus.edu.sg/handle/10635/132833
ISSN: 13595237
DOI: 10.1097/MBP.0b013e32831e30bd
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