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|Title:||Integrin α(v)β3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain Barty|
|Citation:||Nelsen-Salz, B., Eggers, H.J., Zimmermann, H. (1999). Integrin α(v)β3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain Barty. Journal of General Virology 80 (9) : 2311-2313. ScholarBank@NUS Repository.|
|Abstract:||The enterovirus echovirus 9 strain Barry (E9/Barty) is pathogenic for newborn mice as well as for humans. In contrast to the apathogenic prototype strain Hill, strain Barty encodes an RGD motif in the C-terminal part of the structural protein VP1. Data are presented that show that E9/Barty binds its target cells via contact of the RGD motif to the α(v)β3 integrin (vitronectin receptor), whereas prototype Hill uses a different, still unidentified receptor site. Furthermore, virus titres of murine muscle tissue were compared after infection of newborn and 1-, 2-, 3- and 12-week-old mice. The replication capacity of the virus decreased dramatically with age of the infected mice. Since E9/Barty does not replicate or replicates only poorly in mice older than about 5 days, and expression of the vitronectin receptor is reported to be down-regulated in striated muscle tissue during development, it is suggested that susceptibility of mice to this echovirus infection is controlled by the availability of α(v)β3 integrin.|
|Source Title:||Journal of General Virology|
|Appears in Collections:||Staff Publications|
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