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|Title:||Inhibition of lymphocyte proliferation by sera from patients with hepatocellular carcinoma: Lack of correlation with serum alpha-fetoprotein levels|
|Authors:||Ren, E.C. |
|Citation:||Ren, E.C., Chan, S.H. (1981). Inhibition of lymphocyte proliferation by sera from patients with hepatocellular carcinoma: Lack of correlation with serum alpha-fetoprotein levels. Journal of the National Cancer Institute 66 (4) : 625-630. ScholarBank@NUS Repository.|
|Abstract:||Sera from 23 hepatocellular carcinoma (HCC) patients were studied for their effects on lymphocyte proliferation during polyclonal mitogen stimulation and one-way mixed lymphocyte culture (MLC). The effect of 25% HCC serum on tritiated thymidine uptake of cultures varied from slight augmentation to 95% inhibition; however, no relationship was found between the potency of inhibition and serum alpha-fetoprotein (AFP) concentration. Purified AFP from the ascitic fluid of an HCC patient had no effect on MLC or cultures containing pokeweed mitogen; but at a concentration of 200 μg/ml, AFP inhibited up to 30% of the proliferative responses in cultures containing phytohemagglutinin or concanavalin A. Results strongly suggest that the AFP in HCC sera is not inhibitory in itself.|
|Source Title:||Journal of the National Cancer Institute|
|Appears in Collections:||Staff Publications|
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