Please use this identifier to cite or link to this item: https://doi.org/10.1378/chest.128.1.424
Title: Inhalational nickel carbonyl poisoning in waste processing workers
Authors: Seet, R.C.S. 
Johan, A.
Teo, C.E.S.
Gan, S.L.
Lee, K.H. 
Keywords: Chelation therapy
Clinical features
Nickel carbonyl
Issue Date: Jul-2005
Source: Seet, R.C.S., Johan, A., Teo, C.E.S., Gan, S.L., Lee, K.H. (2005-07). Inhalational nickel carbonyl poisoning in waste processing workers. Chest 128 (1) : 424-429. ScholarBank@NUS Repository. https://doi.org/10.1378/chest.128.1.424
Abstract: Background: Nickel carbonyl is formed when carbon monoxide comes into contact with active nickel. The inhaled nickel carbonyl is rapidly absorbed and distributed mainly to the lungs, brain, adrenal glands, and kidneys. In severe cases, acute nickel carbonyl exposure has been reported to cause death. Design: Descriptive study. Patients: Seven young men presented with fever, chills, substernal pleuritic chest pain, and exertional dyspnea. Extensive microbiological and toxicological investigations (including blood, urine, and bronchial specimens) for known pathogens and occupational toxins were performed. The clinical course and radiologic findings of each patient, including autopsy findings of three patients who died, were described. Results: Four patients received treatment in the ICU. Elevated urinary nickel concentration was detected in all patients. Results of extensive microbiological investigations were unremarkable. No patients received chelating agents. Pulmonary consolidation, edema, hemorrhage, and fibrosis were observed at autopsy in patients who died. An out-of-date chemical used during neutralization of nickel waste was implicated as the source of nickel carbonyl poisoning. Conclusions: High mortality was reported in patients who presented subacutely following nickel carbonyl exposure. Further studies should be performed to clarify the role of chelation therapy in the subacute phases following nickel carbonyl exposure.
Source Title: Chest
URI: http://scholarbank.nus.edu.sg/handle/10635/131518
ISSN: 00123692
DOI: 10.1378/chest.128.1.424
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Jan 17, 2018

WEB OF SCIENCETM
Citations

4
checked on Nov 17, 2017

Page view(s)

5
checked on Jan 14, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.