Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13132
Title: Oxidative Damage and Immunological Responses in Ageing Hybrid Mice with Resveratrol Intervention
Authors: WONG YEE TING
Keywords: Resveratrol, ageing, oxidative damage, immunological responses, F2 hybrid mice
Issue Date: 6-Jun-2008
Source: WONG YEE TING (2008-06-06). Oxidative Damage and Immunological Responses in Ageing Hybrid Mice with Resveratrol Intervention. ScholarBank@NUS Repository.
Abstract: Resveratrol (RSV), a natural phytoalexin found in red wine has been shown to extend mean and maximum life span in organisms. Our study in F2 four-way cross hybrid mice evaluated the effects of ageing and long-term RSV treatment in drinking water for 6 or 12 months on biomarkers of oxidative damage and immunological responses. In the majority of tissues, there was a significant age-dependent accumulation of oxidative damage to DNA, lipid, protein and a clear increase in urine 8-Iso-prostaglandin2alpha (8-Iso-PGF2alpha) levels. Chronic RSV treatment elevated total RSV plasma levels and reduced age-dependent accumulation of 8-hydroxy-2'-deoxyguanosine in liver and heart; 8-Iso-PGF2alpha in heart and urine; and protein carbonyl content in liver and kidney. RSV intake ameliorated the age-related decline in phagocytic capability of granulocytes and T lymphoproliferation activity. The old RSV treated mice maintained cytokine profiles similar to that of a younger cohort with some pro-inflammatory and anti-inflammatory cytokines being elevated.
URI: http://scholarbank.nus.edu.sg/handle/10635/13132
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
WongYT.pdf2.11 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

313
checked on Dec 2, 2017

Download(s)

367
checked on Dec 2, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.