Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.femsle.2004.12.028
Title: | Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels |
Authors: | Taylor, M.B. Oh, J.H.L. Kang, K.L. Chow, V.T.K. |
Keywords: | Intermedilysin Streptococcus intermedius Sub-minimum inhibitory concentration |
Issue Date: | 15-Feb-2005 |
Citation: | Taylor, M.B., Oh, J.H.L., Kang, K.L., Chow, V.T.K. (2005-02-15). Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels. FEMS Microbiology Letters 243 (2) : 379-384. ScholarBank@NUS Repository. https://doi.org/10.1016/j.femsle.2004.12.028 |
Abstract: | Intermedilysin is a cytolytic toxin produced by Streptococcus intermedius, a pathogen of humans. In vitro studies showed that exposure of S. intermedius to sub-minimum inhibitory concentration (MIC) levels (1/2 MIC) of protein-inhibiting antibiotics and nucleic acid-inhibiting antibiotics decreased intermedilysin release by S. intermedius. The most potent antibiotic was clindamycin. On the other hand, exposure to cell wall-inhibiting antibiotics generally showed insignificant changes in intermedilysin release at sub-MIC concentrations. Investigations into possible mechanisms underlying this sub-MIC effect with clindamycin showed that there was selective decrease in biosynthesis and release of toxin after exposure to 1/2 MIC condition. However, no significant differences in the mRNA levels of the intermedilysin gene were observed. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. |
Source Title: | FEMS Microbiology Letters |
URI: | http://scholarbank.nus.edu.sg/handle/10635/131255 |
ISSN: | 03781097 |
DOI: | 10.1016/j.femsle.2004.12.028 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
5
checked on Feb 20, 2019
WEB OF SCIENCETM
Citations
4
checked on Feb 12, 2019
Page view(s)
27
checked on Feb 8, 2019
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.