Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131130
Title: Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome
Authors: Hande, M.P. 
Azizova, T.V.
Geard, C.R.
Burak, L.E.
Mitchell, C.R.
Khokhryakov, V.F.
Vasilenko, E.K.
Brenner, D.J.
Issue Date: 1-May-2003
Citation: Hande, M.P., Azizova, T.V., Geard, C.R., Burak, L.E., Mitchell, C.R., Khokhryakov, V.F., Vasilenko, E.K., Brenner, D.J. (2003-05-01). Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 72 (5) : 1162-1170. ScholarBank@NUS Repository.
Abstract: Speculation has long surrounded the question of whether past exposure to ionizing radiation leaves a unique permanent signature in the genome. Intrachromosomal rearrangements or deletions are produced much more efficiently by densely ionizing radiation than by chemical mutagens, x-rays, or endogenous aging processes. Until recently, such stable intrachromosomal aberrations have been very hard to detect, but a new chromosome band painting technique has made their detection practical. We report the detection and quantification of stable intrachromosomal aberrations in lymphocytes of healthy former nuclear-weapons workers who were exposed to plutonium many years ago. Even many years after occupational exposure, more than half the blood cells of the healthy plutonium workers contain large (>6 Mb) intrachromosomal rearrangements. The yield of these aberrations was highly correlated with plutonium dose to the bone marrow. The control groups contained very few such intrachromosomal aberrations. Quantification of this large-scale chromosomal damage in human populations exposed many years earlier will lead to new insights into the mechanisms and risks of cytogenetic damage.
Source Title: American Journal of Human Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/131130
ISSN: 00029297
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

102
checked on May 10, 2018

WEB OF SCIENCETM
Citations

96
checked on May 16, 2018

Page view(s)

23
checked on Jun 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.