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|Title:||Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome|
|Authors:||Hande, M.P. |
|Citation:||Hande, M.P., Azizova, T.V., Geard, C.R., Burak, L.E., Mitchell, C.R., Khokhryakov, V.F., Vasilenko, E.K., Brenner, D.J. (2003-05-01). Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 72 (5) : 1162-1170. ScholarBank@NUS Repository.|
|Abstract:||Speculation has long surrounded the question of whether past exposure to ionizing radiation leaves a unique permanent signature in the genome. Intrachromosomal rearrangements or deletions are produced much more efficiently by densely ionizing radiation than by chemical mutagens, x-rays, or endogenous aging processes. Until recently, such stable intrachromosomal aberrations have been very hard to detect, but a new chromosome band painting technique has made their detection practical. We report the detection and quantification of stable intrachromosomal aberrations in lymphocytes of healthy former nuclear-weapons workers who were exposed to plutonium many years ago. Even many years after occupational exposure, more than half the blood cells of the healthy plutonium workers contain large (>6 Mb) intrachromosomal rearrangements. The yield of these aberrations was highly correlated with plutonium dose to the bone marrow. The control groups contained very few such intrachromosomal aberrations. Quantification of this large-scale chromosomal damage in human populations exposed many years earlier will lead to new insights into the mechanisms and risks of cytogenetic damage.|
|Source Title:||American Journal of Human Genetics|
|Appears in Collections:||Staff Publications|
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