Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2121-5-49
Title: Regulation of cell cycle by the anaphase spindle midzone
Authors: Murata-Hori, M. 
Sluder, G.
Wang, Y.-L.
Issue Date: 23-Dec-2004
Citation: Murata-Hori, M., Sluder, G., Wang, Y.-L. (2004-12-23). Regulation of cell cycle by the anaphase spindle midzone. BMC Cell Biology 5 : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2121-5-49
Abstract: Background: A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle. Results: We microsurgically severed NRK epithelial cells during anaphase or telophase, such that the spindle midzone/midbody was associated with only one of the daughter cells. Time-lapse recording of cells severed during early anaphase indicated that the cell with midzone underwent cytokinesis-like cortical contractions and progressed normally through the interphase, whereas the cell without midzone showed no cortical contraction and an arrest or substantial delay in the progression of interphase. Similar microsurgery during telophase showed a normal progression of interphase for both daughter cells with or without the midbody. Microsurgery of anaphase cells treated with cytochalasin D or nocodazole indicated that interphase progression was independent of cortical ingression but dependent on microtubules. Conclusions: We conclude that the mitotic spindle is involved in not only the separation of chromosomes but also the regulation of cell cycle. The process may involve activation of components in the spindle midzone that are required for the cell cycle, and/or degradation of components that are required for cytokinesis but may interfere with the cell cycle. © 2004 Murata-Hori et al; licensee BioMed Central Ltd.
Source Title: BMC Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/130421
ISSN: 14712121
DOI: 10.1186/1471-2121-5-49
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Dec 11, 2018

WEB OF SCIENCETM
Citations

2
checked on Dec 3, 2018

Page view(s)

9
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.