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Title: Therapeutic vaccination and novel strategies to treat chronic HBV infection
Authors: Bertoletti, A. 
Gehring, A.
Keywords: PD-1
T-cell deletion
T-cell exhaustion
T-cell receptor therapy
Viral hepatitis
Issue Date: Oct-2009
Citation: Bertoletti, A., Gehring, A. (2009-10). Therapeutic vaccination and novel strategies to treat chronic HBV infection. Expert Review of Gastroenterology and Hepatology 3 (5) : 561-569. ScholarBank@NUS Repository.
Abstract: Therapeutic vaccination for the treatment of chronic hepatitis B has so far shown limited clinical efficacy. In this review, we argue that the principal cause of this failure is the profound defect of virus-specific T cells present in chronic hepatitis B patients and we discuss potential new ways to achieve an efficient restoration of virus-specific immunity in patients with chronic hepatitis B virus infection. © 2009 Expert Reviews Ltd.
Source Title: Expert Review of Gastroenterology and Hepatology
ISSN: 17474124
DOI: 10.1586/egh.09.48
Appears in Collections:Staff Publications

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