Please use this identifier to cite or link to this item: https://doi.org/10.1002/em.20528
Title: Centrosomes and myeloma; aneuploidy and proliferation
Authors: Chng, W.J. 
Fonseca, R.
Keywords: Aneuploidy
Centrosomes
Genetics
Myeloma
Issue Date: Oct-2009
Citation: Chng, W.J., Fonseca, R. (2009-10). Centrosomes and myeloma; aneuploidy and proliferation. Environmental and Molecular Mutagenesis 50 (8) : 697-707. ScholarBank@NUS Repository. https://doi.org/10.1002/em.20528
Abstract: Multiple myeloma is the second most common hematological malignancy in the United States. The disease is characterized by an accumulation of clonal plasma cells. Clinically, patients present with anemia, lytic bone lesions, hypercalcaemia, or renal impairment. The genome of the malignant plasma cells is extremely unstable and is typically aneuploid and characterized by a complex combination of structure and numerical abnormalities. The basis of the genomic instability underlying myeloma is unclear. In this regard, centrosome amplification is present in about a third of myeloma and may represent a mechanism leading to genomic instability in myeloma. Centrosome amplification is associated with high-risk features and poor prognosis. Understanding the underlying etiology of centrosome amplification in myeloma may lead to new therapeutic avenues. © 2009 Wiley-Liss, Inc.
Source Title: Environmental and Molecular Mutagenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/129856
ISSN: 08936692
DOI: 10.1002/em.20528
Appears in Collections:Staff Publications

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