Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.pediatrneurol.2007.02.005
Title: Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome
Authors: Chan, D.W.S.
Lim, C.C.T. 
Tay, S.K.H. 
Choong, C.-T. 
Phuah, H.K.
Issue Date: Jun-2007
Citation: Chan, D.W.S., Lim, C.C.T., Tay, S.K.H., Choong, C.-T., Phuah, H.K. (2007-06). Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome. Pediatric Neurology 36 (6) : 414-417. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pediatrneurol.2007.02.005
Abstract: Both the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) and Hashimoto's encephalopathy can present with nonspecific encephalopathy. Hashimoto's encephalopathy is an association of steroid-responsive encephalopathy with elevated thyroid peroxidase antibodies. Steroid-responsive encephalopathy, however, is not characteristic of the MELAS syndrome, which typically presents with stroke-like episodes and lactic acidosis in cerebrospinal fluid and blood. Here, a patient is described with goiter, recurrent encephalopathy and elevated thyroid peroxidase antibodies who apparently responded to steroid therapy; however, magnetic resonance imaging was atypical for Hashimoto's encephalopathy, and she was diagnosed with MELAS syndrome. This syndrome can present with apparent steroid-responsive encephalopathy and elevated thyroid peroxidase antibodies, mimicking Hashimoto's encephalopathy, and should be suspected if lactic acidosis is present and typical features are detected on magnetic resonance imaging. © 2007 Elsevier Inc. All rights reserved.
Source Title: Pediatric Neurology
URI: http://scholarbank.nus.edu.sg/handle/10635/129743
ISSN: 08878994
DOI: 10.1016/j.pediatrneurol.2007.02.005
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