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|Title:||Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome|
|Citation:||Chan, D.W.S., Lim, C.C.T., Tay, S.K.H., Choong, C.-T., Phuah, H.K. (2007-06). Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome. Pediatric Neurology 36 (6) : 414-417. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pediatrneurol.2007.02.005|
|Abstract:||Both the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) and Hashimoto's encephalopathy can present with nonspecific encephalopathy. Hashimoto's encephalopathy is an association of steroid-responsive encephalopathy with elevated thyroid peroxidase antibodies. Steroid-responsive encephalopathy, however, is not characteristic of the MELAS syndrome, which typically presents with stroke-like episodes and lactic acidosis in cerebrospinal fluid and blood. Here, a patient is described with goiter, recurrent encephalopathy and elevated thyroid peroxidase antibodies who apparently responded to steroid therapy; however, magnetic resonance imaging was atypical for Hashimoto's encephalopathy, and she was diagnosed with MELAS syndrome. This syndrome can present with apparent steroid-responsive encephalopathy and elevated thyroid peroxidase antibodies, mimicking Hashimoto's encephalopathy, and should be suspected if lactic acidosis is present and typical features are detected on magnetic resonance imaging. © 2007 Elsevier Inc. All rights reserved.|
|Source Title:||Pediatric Neurology|
|Appears in Collections:||Staff Publications|
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