Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/12941
Title: In vitro drug release mechanism from cholesteryl ester-composed liquid crystalline system
Authors: WU JIAO
Keywords: ibuprofen, cholesteryl ester, liquid crystal, in vitro, drug release, mechanism
Issue Date: 1-Mar-2009
Source: WU JIAO (2009-03-01). In vitro drug release mechanism from cholesteryl ester-composed liquid crystalline system. ScholarBank@NUS Repository.
Abstract: The present study has investigated the in vitro ibuprofen release profiles from a liquid crystalline system, which is composed of cholesteryl nonanoate (CNN), cholesteryl chloride (CCL) and cholesteryl oleyl carbonate (COC), with a combination ratio of CNN/COC/CCL=10/80/10 w/w/w. The presence of organized liquid crystalline structures was confirmed by polarizing light microscopy and x-ray diffraction, and the structures were shown to remain relatively unchanged after drug loading. The inclusion drug molecules remained in a molecularly distributed amorphous state as no crystalline drug evidence was found in the matrix as shown by DSC and x-ray diffraction studies. The in vitro ibuprofen release profiles most aptly fitted to the square root Higuchi release model, indicating that drug release was predominantly controlled by Fickian diffusion. Drug release was influenced by the phase transition of the liquid crystalline matrix, initial drug loading, as well as the viscosity of the matrix system.
URI: http://scholarbank.nus.edu.sg/handle/10635/12941
Appears in Collections:Master's Theses (Open)

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