Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/12928
Title: Investigation on factors affecting drug delivery using polymers and phospholipids.
Authors: ANAHITA FATHI-AZARBAYJANI
Keywords: Skin Permeation, Drug Delivery, Polymers, Phospholipids, Drug Physicochemical Characteristics, Carrier Structure
Issue Date: 29-Apr-2009
Source: ANAHITA FATHI-AZARBAYJANI (2009-04-29). Investigation on factors affecting drug delivery using polymers and phospholipids.. ScholarBank@NUS Repository.
Abstract: The aim of this thesis was to investigate the influence of physicochemical characteristics of the drug and the carrier on the topical or transdermal permeation of hydrophilic (ascorbic acid, diclofenac) and lipophilic drug molecules (levothyroxine, haloperidol, retinoic acid) from polymeric, poly-N-isoporopylacrylamide (PNIPAM), poly vinylalcohol, randomly methylated N2-cyclodextrin (RM N2-CD), poly lactide , poly lactide co-glycolide, ethyl cellulose, nanofibers and microparticles and various lipid vesicles using excised human skin. RM N2-CD decreased the degradation time of the nanofiber mat from a few weeks to a few seconds and provided rapid drug release, whereas PNIPAM nanofibers sustained the skin delivery of the drug. An anti-wrinkle face mask was developed to increase the stability of ascorbic acid and the aqueous solubility of retinoic acid. It was found that modification of physicochemical characteristics of the drug and carrier can be used to increase the skin permeation/accumulation of drugs.
URI: http://scholarbank.nus.edu.sg/handle/10635/12928
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
thesis part 1.pdf85.06 kBAdobe PDF

OPEN

NoneView/Download
thesis part 2.pdf962.05 kBAdobe PDF

OPEN

NoneView/Download
thesis part 3.pdf895.27 kBAdobe PDF

OPEN

NoneView/Download
thesis part 4.pdf1.73 MBAdobe PDF

OPEN

NoneView/Download
thesis part 5.pdf1.48 MBAdobe PDF

OPEN

NoneView/Download
TITLE PAGE.pdf3.05 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

348
checked on Dec 11, 2017

Download(s)

2,292
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.