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|Title:||Altered fibrinolysis in DVT: Influence of site of sampling|
|Authors:||Han, P. |
|Source:||Han, P.,Koay, E.S.C.,Tsakok, M.,Aw, T.C.,Wong, L.Y.,Pradhan, M. (1988). Altered fibrinolysis in DVT: Influence of site of sampling. Thrombosis and Haemostasis 60 (1) : 50-53. ScholarBank@NUS Repository.|
|Abstract:||Alteration of the fibrinolytic system is considered to be important in the development of deep venous thrombosis (DVT). Using specific assays for tissue plasminogen activator (t-PA) activity, t-PA inhibitor (PAI) and t-PA antigen, we measured these activities in 16 women who developed DVT during their pregnancies. A group of 24 healthy females of comparable age was studied as controls. PAI was increased in 87% of these patients compared to the healthy controls. In some of these patients a defect in release of t-PA from vascular endothelium was found as well. The site at which blood was sampled for analysis appeared to be an important criterion in the ex vivo assessment of functional t-PA reserve and PAI levels, though relatively less so for the latter measurement. The unaffected lower limbs, relative to the unaffected upper limbs, showed an increase in PAI and a demonstrable decrease in t-PA release, both representing increased risk factors for rethrombosis. The affected lower limbs showed similar but more accentuated changes in these parameters.|
|Source Title:||Thrombosis and Haemostasis|
|Appears in Collections:||Staff Publications|
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