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|Title:||A prospective randomized comparison of single versus multidose gentamicin in the treatment of CAPD peritonitis.|
van der Straaten, J.C.
|Citation:||Lye, W.C.,Wong, P.L.,van der Straaten, J.C.,Leong, S.O.,Lee, E.J. (1995). A prospective randomized comparison of single versus multidose gentamicin in the treatment of CAPD peritonitis.. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 11 : 179-181. ScholarBank@NUS Repository.|
|Abstract:||There is an increasing trend towards the use of aminoglycosides in a once-daily dose administration for the treatment of severe infections in nonrenal failure patients. The use of once-daily dose aminoglycoside therapy may be associated with a reduction in toxicity. We performed a prospective randomized study comparing once-daily versus multiple-dose gentamicin in the treatment of continuous ambulatory peritoneal dialysis (CAPD) peritonitis. Seventy-three patients with 100 new episodes of peritonitis were enrolled in the study. At presentation of peritonitis, the patients were alternately assigned to receive either intraperitoneal gentamicin at a dose of 40 mg/2 L dialysate administered as a once-daily dose or gentamicin at a dose of 10mg/2 L dialysate administered 4 times per day. All patients also received intraperitoneal vancomycin at a dose of 1 g per week. There were no significant differences in the treatment success (88% vs 82%, p = NS) and relapse (18% vs 20%, p = NS) rates between the once-daily dose and multiple-dose groups. The mean trough serum gentamicin level was higher in the once-daily dose group compared to the multiple-dose group (0.75 +/- 0.72 vs 1.50 +/- 1.40 mg/L). In conclusion, gentamicin administered in a once-daily dose is as effective as multiple-dose administration in the treatment of CAPD peritonitis. The lower gentamicin level with once-daily dose administration may be associated with a reduction in aminoglycoside toxicity.|
|Source Title:||Advances in peritoneal dialysis. Conference on Peritoneal Dialysis|
|Appears in Collections:||Staff Publications|
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