Please use this identifier to cite or link to this item: https://doi.org/10.1128/JVI.00748-10
Title: The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor
Authors: Karjee, S.
Minhas, A.
Sood, V.
Ponia, S.S.
Banerjea, A.C.
Chow, V.T.K. 
Mukherjee, S.K.
Lal, S.K.
Issue Date: Oct-2010
Citation: Karjee, S., Minhas, A., Sood, V., Ponia, S.S., Banerjea, A.C., Chow, V.T.K., Mukherjee, S.K., Lal, S.K. (2010-10). The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor. Journal of Virology 84 (19) : 10395-10401. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.00748-10
Abstract: RNA silencing suppressors (RSSs) are well studied for plant viruses but are not well defined to date for animal viruses. Here, we have identified an RSS from a medically important positive-sense mammalian virus, Severe acute respiratory syndrome coronavirus. The viral 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA (siRNA). The suppression of silencing was analyzed by two independent assays, and the middle region (amino acids [aa] 32 to 89) of 7a was responsible for suppression. Finally, the RNA suppression property and the enhancement of heterologous replicon activity by the 7a protein were confirmed for animal cell lines. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Source Title: Journal of Virology
URI: http://scholarbank.nus.edu.sg/handle/10635/128964
ISSN: 0022538X
DOI: 10.1128/JVI.00748-10
Appears in Collections:Staff Publications

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