Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/128794
Title: SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURE-INSPIRED N-HYDROXYPYRIDONES AND THEIR DERIVATIVES
Authors: TENG YANBO
Keywords: N-hydroxypyridone, natural product, anti-plasmodial, antibacterial, iron-chelation
Issue Date: 31-Mar-2016
Citation: TENG YANBO (2016-03-31). SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURE-INSPIRED N-HYDROXYPYRIDONES AND THEIR DERIVATIVES. ScholarBank@NUS Repository.
Abstract: Malaria is an infectious disease causing deaths of thousands of children. The eradication of malaria remains as a big challenge in the world. N-hydroxypyridone natural products have been reported to display a range if biological activities, including anti-malarial properties. However, the total synthesis of naturally occurring N-hydroxypyridones and the full scope of the biological activities of these compounds remain largely unexplored. This project commenced with the total synthesis of cordypyridones and pyridoxatin. Four synthetic routes were thoroughly investigated and a novel methodology was developed. Two libraries of N-hydroxypyridones were synthesized. The anti-plasmodial, anti-bacterial and anti-oxidant activities of these two libraries of compounds were evaluated. Three compounds were identified as leads. An iron chelation study was also conducted to evaluate the properties of N-hydroxy-2-pyridone motif. The results showed that compounds with N-hydroxy-2-pyridone motif are good iron chelators as compared with EDTA.
URI: http://scholarbank.nus.edu.sg/handle/10635/128794
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Teng YB.pdf18.59 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

47
checked on Dec 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.