Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/12877
Title: Experimental investigation on the applicability of FBRM in the control of batch cooling crystallization
Authors: CHEW JIA WEI
Keywords: batch cooling crystallization, ATR-FTIR, FBRM, feedback loop, PAT
Issue Date: 13-Mar-2007
Source: CHEW JIA WEI (2007-03-13). Experimental investigation on the applicability of FBRM in the control of batch cooling crystallization. ScholarBank@NUS Repository.
Abstract: Consistent particle properties are an important goal for industrial batchcrystallizations. Several control strategies, from unseeded linear cooling toseeded supersaturation control, were evaluated for the cooling crystallization ofglycine. Particle properties were assessed in-line using ATR-FTIR, FBRM, andPVM. Closed-loop supersaturation-control was not superior to open-looptemperature-control, and seeding was by far the most effective strategy in thiscomparison. Unseeded systems do not achieve consistency, because primarynucleation is unpredictable and irreproducible. In this work,the FBRM was successfully used to detect primary nucleation, after which controlstrategies were automatically implemented in unseeded cooling crystallizationsystems. A novel technique to counter the problem of inconsistent crystalproducts due to randomness of primary nuclei was also proposed. This employsFBRM in a closed feedback loop, which involves adjusting the coefficient ofvariance (c.v.) of the primary nuclei. Consistent crystal products from unseededsystems were hence achievable.
URI: http://scholarbank.nus.edu.sg/handle/10635/12877
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Chew Jia Wei.pdf1.88 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

267
checked on Dec 11, 2017

Download(s)

554
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.