Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion

Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jgg.2014.03.003

Title:	Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion
Authors:	Tan, J.S.Y. Seow, C.J.P. Goh, V.J. Silver, D.L.
Keywords:	LD-associated proteins Lipid droplets Perilipin Phospholipids
Issue Date:	20-May-2014
Citation:	Tan, J.S.Y., Seow, C.J.P., Goh, V.J., Silver, D.L. (2014-05-20). Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion. Journal of Genetics and Genomics 41 (5) : 251-259. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jgg.2014.03.003
Abstract:	Lipid droplets (LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein (Fsp27), fat storage-inducing transmembrane (FIT) proteins, seipin and ADP-ribosylation factor 1-coat protein complex I (Arf-COPI). Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved. © 2014.
Source Title:	Journal of Genetics and Genomics
URI:	http://scholarbank.nus.edu.sg/handle/10635/128660
ISSN:	18735533
DOI:	10.1016/j.jgg.2014.03.003
Appears in Collections:	Staff Publications

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