Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2711
Title: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Authors: Lee, S.H.
Ripke, S.
Neale, B.M.
Faraone, S.V.
Purcell, S.M.
Perlis, R.H.
Mowry, B.J.
Thapar, A.
Goddard, M.E.
Witte, J.S.
Absher, D.
Agartz, I.
Akil, H.
Amin, F.
Andreassen, O.A.
Anjorin, A.
Anney, R.
Anttila, V.
Arking, D.E.
Asherson, P.
Azevedo, M.H.
Backlund, L.
Badner, J.A.
Bailey, A.J.
Banaschewski, T.
Barchas, J.D.
Barnes, M.R.
Barrett, T.B.
Bass, N.
Battaglia, A.
Bauer, M.
Bayés, M.
Bellivier, F.
Bergen, S.E.
Berrettini, W.
Betancur, C.
Bettecken, T.
Biederman, J.
Binder, E.B.
Black, D.W.
Blackwood, D.H.R.
Bloss, C.S.
Boehnke, M.
Boomsma, D.I.
Breen, G.
Breuer, R.
Bruggeman, R.
Cormican, P.
Buccola, N.G.
Buitelaar, J.K.
Bunney, W.E.
Buxbaum, J.D.
Byerley, W.F.
Byrne, E.M.
Caesar, S.
Cahn, W.
Cantor, R.M.
Casas, M.
Chakravarti, A.
Chambert, K.
Choudhury, K.
Cichon, S.
Cloninger, C.R.
Collier, D.A.
Cook, E.H.
Coon, H.
Cormand, B.
Corvin, A.
Coryell, W.H.
Craig, D.W.
Craig, I.W.
Crosbie, J.
Cuccaro, M.L.
Curtis, D.
Czamara, D.
Datta, S.
Dawson, G.
Day, R.
De Geus, E.J.
Degenhardt, F.
Djurovic, S.
Donohoe, G.J.
Doyle, A.E.
Duan, J.
Dudbridge, F.
Duketis, E.
Ebstein, R.P. 
Edenberg, H.J.
Elia, J.
Ennis, S.
Etain, B.
Fanous, A.
Farmer, A.E.
Ferrier, I.N.
Flickinger, M.
Fombonne, E.
Foroud, T.
Frank, J.
Franke, B.
Fraser, C.
Freedman, R.
Freimer, N.B.
Freitag, C.M.
Friedl, M.
Frisén, L.
Gallagher, L.
Gejman, P.V.
Georgieva, L.
Gershon, E.S.
Geschwind, D.H.
Giegling, I.
Gill, M.
Gordon, S.D.
Gordon-Smith, K.
Green, E.K.
Greenwood, T.A.
Grice, D.E.
Gross, M.
Grozeva, D.
Guan, W.
Gurling, H.
De Haan, L.
Haines, J.L.
Hakonarson, H.
Hallmayer, J.
Hamilton, S.P.
Hamshere, M.L.
Hansen, T.F.
Hartmann, A.M.
Hautzinger, M.
Heath, A.C.
Henders, A.K.
Herms, S.
Hickie, I.B.
Hipolito, M.
Hoefels, S.
Holmans, P.A.
Holsboer, F.
Hoogendijk, W.J.
Hottenga, J.-J.
Hultman, C.M.
Hus, V.
Ingason, A.
Ising, M.
Jamain, S.
Jones, E.G.
Jones, I.
Jones, L.
Tzeng, J.-Y.
Kähler, A.K.
Kahn, R.S.
Kandaswamy, R.
Keller, M.C.
Kennedy, J.L.
Kenny, E.
Kent, L.
Kim, Y.
Kirov, G.K.
Klauck, S.M.
Klei, L.
Knowles, J.A.
Kohli, M.A.
Koller, D.L.
Konte, B.
Korszun, A.
Krabbendam, L.
Krasucki, R.
Kuntsi, J.
Kwan, P.
Landén, M.
Långström, N.
Lathrop, M.
Lawrence, J.
Lawson, W.B.
Leboyer, M.
Ledbetter, D.H.
Lee, P.H.
Lencz, T.
Lesch, K.-P.
Levinson, D.F.
Lewis, C.M.
Li, J.
Lichtenstein, P.
Lieberman, J.A.
Lin, D.-Y.
Linszen, D.H.
Liu, C.
Lohoff, F.W.
Loo, S.K.
Lord, C.
Lowe, J.K.
Lucae, S.
Macintyre, D.J.
Madden, P.A.F.
Maestrini, E.
Magnusson, P.K.E.
Mahon, P.B.
Maier, W.
Malhotra, A.K.
Mane, S.M.
Martin, C.L.
Martin, N.G.
Mattheisen, M.
Matthews, K.
Mattingsdal, M.
Mccarroll, S.A.
Mcghee, K.A.
Mcgough, J.J.
Mcgrath, P.J.
Mcguffin, P.
Mcinnis, M.G.
Mcintosh, A.
Mckinney, R.
Mclean, A.W.
Mcmahon, F.J.
Mcmahon, W.M.
Mcquillin, A.
Medeiros, H.
Medland, S.E.
Meier, S.
Melle, I.
Meng, F.
Meyer, J.
Middeldorp, C.M.
Middleton, L.
Milanova, V.
Miranda, A.
Monaco, A.P.
Montgomery, G.W.
Moran, J.L.
Moreno-De-Luca, D.
Morken, G.
Morris, D.W.
Morrow, E.M.
Moskvina, V.
Muglia, P.
Mühleisen, T.W.
Muir, W.J.
Müller-Myhsok, B.
Murtha, M.
Myers, R.M.
Myin-Germeys, I.
Neale, M.C.
Nelson, S.F.
Nievergelt, C.M.
Nikolov, I.
Nimgaonkar, V.
Nolen, W.A.
Nöthen, M.M.
Nurnberger, J.I.
Nwulia, E.A.
Nyholt, D.R.
O'dushlaine, C.
Oades, R.D.
Olincy, A.
Oliveira, G.
Olsen, L.
Ophoff, R.A.
Osby, U.
Owen, M.J.
Palotie, A.
Parr, J.R.
Paterson, A.D.
Pato, C.N.
Pato, M.T.
Penninx, B.W.
Pergadia, M.L.
Pericak-Vance, M.A.
Pickard, B.S.
Pimm, J.
Piven, J.
Posthuma, D.
Potash, J.B.
Poustka, F.
Propping, P.
Puri, V.
Quested, D.J.
Quinn, E.M.
Ramos-Quiroga, J.A.
Rasmussen, H.B.
Raychaudhuri, S.
Rehnström, K.
Reif, A.
Ribasés, M.
Rice, J.P.
Rietschel, M.
Roeder, K.
Roeyers, H.
Rossin, L.
Rothenberger, A.
Rouleau, G.
Ruderfer, D.
Rujescu, D.
Sanders, A.R.
Sanders, S.J.
Santangelo, S.L.
Sergeant, J.A.
Schachar, R.
Schalling, M.
Schatzberg, A.F.
Scheftner, W.A.
Schellenberg, G.D.
Scherer, S.W.
Schork, N.J.
Schulze, T.G.
Schumacher, J.
Schwarz, M.
Scolnick, E.
Scott, L.J.
Shi, J.
Shilling, P.D.
Shyn, S.I.
Silverman, J.M.
Slager, S.L.
Smalley, S.L.
Smit, J.H.
Smith, E.N.
Sonuga-Barke, E.J.S.
St. Clair, D.
State, M.
Steffens, M.
Steinhausen, H.-C.
Strauss, J.S.
Strohmaier, J.
Stroup, T.S.
Sutcliffe, J.S.
Szatmari, P.
Szelinger, S.
Thirumalai, S.
Thompson, R.C.
Todorov, A.A.
Tozzi, F.
Treutlein, J.
Uhr, M.
Van Den Oord, E.J.C.G.
Van Grootheest, G.
Van Os, J.
Vicente, A.M.
Vieland, V.J.
Vincent, J.B.
Visscher, P.M.
Walsh, C.A.
Wassink, T.H.
Watson, S.J.
Weissman, M.M.
Werge, T.
Wienker, T.F.
Wijsman, E.M.
Willemsen, G.
Williams, N.
Willsey, A.J.
Witt, S.H.
Xu, W.
Young, A.H.
Yu, T.W.
Zammit, S.
Zandi, P.P.
Zhang, P.
Zitman, F.G.
Zöllner, S.
Devlin, B.
Kelsoe, J.R.
Sklar, P.
Daly, M.J.
O'donovan, M.C.
Craddock, N.
Sullivan, P.F.
Smoller, J.W.
Kendler, K.S.
Wray, N.R.
Issue Date: Sep-2013
Citation: Lee, S.H., Ripke, S., Neale, B.M., Faraone, S.V., Purcell, S.M., Perlis, R.H., Mowry, B.J., Thapar, A., Goddard, M.E., Witte, J.S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O.A., Anjorin, A., Anney, R., Anttila, V., Arking, D.E., Asherson, P., Azevedo, M.H., Backlund, L., Badner, J.A., Bailey, A.J., Banaschewski, T., Barchas, J.D., Barnes, M.R., Barrett, T.B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S.E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E.B., Black, D.W., Blackwood, D.H.R., Bloss, C.S., Boehnke, M., Boomsma, D.I., Breen, G., Breuer, R., Bruggeman, R., Cormican, P., Buccola, N.G., Buitelaar, J.K., Bunney, W.E., Buxbaum, J.D., Byerley, W.F., Byrne, E.M., Caesar, S., Cahn, W., Cantor, R.M., Casas, M., Chakravarti, A., Chambert, K., Choudhury, K., Cichon, S., Cloninger, C.R., Collier, D.A., Cook, E.H., Coon, H., Cormand, B., Corvin, A., Coryell, W.H., Craig, D.W., Craig, I.W., Crosbie, J., Cuccaro, M.L., Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., De Geus, E.J., Degenhardt, F., Djurovic, S., Donohoe, G.J., Doyle, A.E., Duan, J., Dudbridge, F., Duketis, E., Ebstein, R.P., Edenberg, H.J., Elia, J., Ennis, S., Etain, B., Fanous, A., Farmer, A.E., Ferrier, I.N., Flickinger, M., Fombonne, E., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer, N.B., Freitag, C.M., Friedl, M., Frisén, L., Gallagher, L., Gejman, P.V., Georgieva, L., Gershon, E.S., Geschwind, D.H., Giegling, I., Gill, M., Gordon, S.D., Gordon-Smith, K., Green, E.K., Greenwood, T.A., Grice, D.E., Gross, M., Grozeva, D., Guan, W., Gurling, H., De Haan, L., Haines, J.L., Hakonarson, H., Hallmayer, J., Hamilton, S.P., Hamshere, M.L., Hansen, T.F., Hartmann, A.M., Hautzinger, M., Heath, A.C., Henders, A.K., Herms, S., Hickie, I.B., Hipolito, M., Hoefels, S., Holmans, P.A., Holsboer, F., Hoogendijk, W.J., Hottenga, J.-J., Hultman, C.M., Hus, V., Ingason, A., Ising, M., Jamain, S., Jones, E.G., Jones, I., Jones, L., Tzeng, J.-Y., Kähler, A.K., Kahn, R.S., Kandaswamy, R., Keller, M.C., Kennedy, J.L., Kenny, E., Kent, L., Kim, Y., Kirov, G.K., Klauck, S.M., Klei, L., Knowles, J.A., Kohli, M.A., Koller, D.L., Konte, B., Korszun, A., Krabbendam, L., Krasucki, R., Kuntsi, J., Kwan, P., Landén, M., Långström, N., Lathrop, M., Lawrence, J., Lawson, W.B., Leboyer, M., Ledbetter, D.H., Lee, P.H., Lencz, T., Lesch, K.-P., Levinson, D.F., Lewis, C.M., Li, J., Lichtenstein, P., Lieberman, J.A., Lin, D.-Y., Linszen, D.H., Liu, C., Lohoff, F.W., Loo, S.K., Lord, C., Lowe, J.K., Lucae, S., Macintyre, D.J., Madden, P.A.F., Maestrini, E., Magnusson, P.K.E., Mahon, P.B., Maier, W., Malhotra, A.K., Mane, S.M., Martin, C.L., Martin, N.G., Mattheisen, M., Matthews, K., Mattingsdal, M., Mccarroll, S.A., Mcghee, K.A., Mcgough, J.J., Mcgrath, P.J., Mcguffin, P., Mcinnis, M.G., Mcintosh, A., Mckinney, R., Mclean, A.W., Mcmahon, F.J., Mcmahon, W.M., Mcquillin, A., Medeiros, H., Medland, S.E., Meier, S., Melle, I., Meng, F., Meyer, J., Middeldorp, C.M., Middleton, L., Milanova, V., Miranda, A., Monaco, A.P., Montgomery, G.W., Moran, J.L., Moreno-De-Luca, D., Morken, G., Morris, D.W., Morrow, E.M., Moskvina, V., Muglia, P., Mühleisen, T.W., Muir, W.J., Müller-Myhsok, B., Murtha, M., Myers, R.M., Myin-Germeys, I., Neale, M.C., Nelson, S.F., Nievergelt, C.M., Nikolov, I., Nimgaonkar, V., Nolen, W.A., Nöthen, M.M., Nurnberger, J.I., Nwulia, E.A., Nyholt, D.R., O'dushlaine, C., Oades, R.D., Olincy, A., Oliveira, G., Olsen, L., Ophoff, R.A., Osby, U., Owen, M.J., Palotie, A., Parr, J.R., Paterson, A.D., Pato, C.N., Pato, M.T., Penninx, B.W., Pergadia, M.L., Pericak-Vance, M.A., Pickard, B.S., Pimm, J., Piven, J., Posthuma, D., Potash, J.B., Poustka, F., Propping, P., Puri, V., Quested, D.J., Quinn, E.M., Ramos-Quiroga, J.A., Rasmussen, H.B., Raychaudhuri, S., Rehnström, K., Reif, A., Ribasés, M., Rice, J.P., Rietschel, M., Roeder, K., Roeyers, H., Rossin, L., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders, A.R., Sanders, S.J., Santangelo, S.L., Sergeant, J.A., Schachar, R., Schalling, M., Schatzberg, A.F., Scheftner, W.A., Schellenberg, G.D., Scherer, S.W., Schork, N.J., Schulze, T.G., Schumacher, J., Schwarz, M., Scolnick, E., Scott, L.J., Shi, J., Shilling, P.D., Shyn, S.I., Silverman, J.M., Slager, S.L., Smalley, S.L., Smit, J.H., Smith, E.N., Sonuga-Barke, E.J.S., St. Clair, D., State, M., Steffens, M., Steinhausen, H.-C., Strauss, J.S., Strohmaier, J., Stroup, T.S., Sutcliffe, J.S., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson, R.C., Todorov, A.A., Tozzi, F., Treutlein, J., Uhr, M., Van Den Oord, E.J.C.G., Van Grootheest, G., Van Os, J., Vicente, A.M., Vieland, V.J., Vincent, J.B., Visscher, P.M., Walsh, C.A., Wassink, T.H., Watson, S.J., Weissman, M.M., Werge, T., Wienker, T.F., Wijsman, E.M., Willemsen, G., Williams, N., Willsey, A.J., Witt, S.H., Xu, W., Young, A.H., Yu, T.W., Zammit, S., Zandi, P.P., Zhang, P., Zitman, F.G., Zöllner, S., Devlin, B., Kelsoe, J.R., Sklar, P., Daly, M.J., O'donovan, M.C., Craddock, N., Sullivan, P.F., Smoller, J.W., Kendler, K.S., Wray, N.R. (2013-09). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45 (9) : 984-994. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2711
Abstract: Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. © 2013 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/128593
ISSN: 10614036
DOI: 10.1038/ng.2711
Appears in Collections:Staff Publications

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