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https://doi.org/10.1016/j.bbrc.2014.05.020
| Title: | C-type natriuretic peptide (CNP) signal peptide fragments are present in the human circulation | Authors: | Pemberton, C.J. Siriwardena, M. Kleffmann, T. Richards, A.M. |
Keywords: | Biomarkers CNP Mass spectrometry Myocardial infarction Signal peptide |
Issue Date: | 2014 | Citation: | Pemberton, C.J., Siriwardena, M., Kleffmann, T., Richards, A.M. (2014). C-type natriuretic peptide (CNP) signal peptide fragments are present in the human circulation. Biochemical and Biophysical Research Communications. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2014.05.020 | Abstract: | Background: Signal peptides may be novel biomarkers in cardiovascular diseases. Methods: We developed a novel immunoassay to the signal peptide of preproCNP (CNPsp) and used this to document circulating venous concentrations of CNPsp in normal healthy volunteers (n = 109), regional plasma CNPsp concentrations in patients undergoing clinically indicated catheterisation (n = 24) and temporal CNPsp concentrations in patients with ST-elevation myocardial infarction (STEMI) | Source Title: | Biochemical and Biophysical Research Communications | URI: | http://scholarbank.nus.edu.sg/handle/10635/126880 | ISSN: | 0006291X | DOI: | 10.1016/j.bbrc.2014.05.020 |
| Appears in Collections: | Staff Publications |
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