Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.virol.2013.01.018
Title: Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity
Authors: Durbin, A.P.
Mayer, S.V.
Rossi, S.L.
Amaya-Larios, I.Y.
Ramos-Castaneda, J.
Eong Ooi, E. 
Jane Cardosa, M.
Munoz-Jordan, J.L.
Tesh, R.B.
Messer, W.B.
Weaver, S.C.
Vasilakis, N.
Keywords: Antigenic relationships
Dengue virus (DENV)
Human DENV
Plaque reduction neutralization test (PRNT)
Sylvatic DENV
Vaccine
Issue Date: 25-Apr-2013
Citation: Durbin, A.P., Mayer, S.V., Rossi, S.L., Amaya-Larios, I.Y., Ramos-Castaneda, J., Eong Ooi, E., Jane Cardosa, M., Munoz-Jordan, J.L., Tesh, R.B., Messer, W.B., Weaver, S.C., Vasilakis, N. (2013-04-25). Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity. Virology 439 (1) : 34-41. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virol.2013.01.018
Abstract: Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, this potential of emergence into the human transmission cycle could limit the potential for eradicating this cycle with vaccines currently in late stages of development. We assessed the likelihood of sylvatic DENV-4 emergence in the face of natural immunity to current human strains and vaccination with two DENV-4 vaccine candidates. Our data indicate homotypic neutralization of sylvatic and human DENV-4 strains by human primary convalescent and vaccinee sera but limited heterotypic immunity. These results suggest that emergence of sylvatic strains into the human cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies produced by natural infection or vaccination. © 2013 Elsevier Inc.
Source Title: Virology
URI: http://scholarbank.nus.edu.sg/handle/10635/126723
ISSN: 00426822
DOI: 10.1016/j.virol.2013.01.018
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