Please use this identifier to cite or link to this item: https://doi.org/10.1113/expphysiol.2010.055731
Title: Optogenetic probing of functional brain circuitry
Authors: Mancuso, J.J. 
Kim, J. 
Lee, S. 
Tsuda, S. 
Chow, N.B.H.
Augustine, G.J.
Issue Date: Jan-2010
Citation: Mancuso, J.J., Kim, J., Lee, S., Tsuda, S., Chow, N.B.H., Augustine, G.J. (2010-01). Optogenetic probing of functional brain circuitry. Experimental Physiology 96 (1) : 26-33. ScholarBank@NUS Repository. https://doi.org/10.1113/expphysiol.2010.055731
Abstract: Recently developed optogenetic technologies offer the promise of high-speed mapping of brain circuitry. Genetically targeted light-gated channels and pumps, such as channelrhodopsins and halorhodopsin, allow optical control of neuronal activity with high spatial and temporal resolution. Optogenetic probes of neuronal activity, such as Clomeleon and Mermaid, allow light to be used to monitor the activity of a genetically defined population of neurons. Combining these two complementary sets of optogenetic probes will make it possible to perform all-optical circuit mapping. Owing to the improved efficiency and higher speed of data acquisition, this hybrid approach should enable high-throughput mapping of brain circuitry. © 2010 The Authors. Journal compilation © 2011 The Physiological Society.
Source Title: Experimental Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/126588
ISSN: 09580670
DOI: 10.1113/expphysiol.2010.055731
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