Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/126044
Title: BISGUANIDINIUM CATALYZED ENANTIOSELECTIVE PHASE-TRANSFER DESYMMETRIZATIONS
Authors: CHEN LI
Keywords: desymmetrizations, phase-transfer catalysis, bisguanidinium
Issue Date: 30-Nov-2015
Abstract: NOVEL TYPES OF CHIRAL PHASE TRANSFER CATALYSTS PENTANIDIUM SALTS, BIGUANIDINIUM SALTS AND TRISGUANIDINIUM SALTS WERE DESIGNED, SYNTHESIZED AND CHARACTERIZED. THE SYNTHETIC PROCEDURE WAS ALSO OPTIMIZED TO BE MORE SIMPLIFIED AND ENABLE MORE MODIFICATION ON THE CATALYSTS? STRUCTURES, AND GRAM-SCALE SYNTHESIS OF THE CATALYSTS WAS ALSO REALIZED. BY EMPLOYING THOSE CHIRAL PHASE-TRANSFER CATALYSTS, WE STUDIED THE DESYMMETRIZATION OF DIBROMOKETONES WITH VARIOUS ALIPHATIC AND AROMATIC ACETATES. WITH THE OPTIMIZED CONDITION, EXCELLENT YIELDS (UP TO 96%) AND EE VALUES (UP TO 90%) COULD BE ACHIEVED. FURTHER TRANSFORMATION OF THE PRODUCTS TOWARDS MULTICYCLIC STRUCTURES WAS EXPLORED. THE REACTION MECHANISM WAS ALSO STUDIED BASED ON EXPERIMENTAL RESULTS.
URI: http://scholarbank.nus.edu.sg/handle/10635/126044
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChenLi.pdf12.52 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

50
checked on Oct 26, 2018

Download(s)

24
checked on Oct 26, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.