Please use this identifier to cite or link to this item: https://doi.org/10.1146/annurev-immunol-032712-095951
Title: Regulation of ligands for the NKG2D activating receptor
Authors: Raulet, D.H.
Gasser, S. 
Gowen, B.G.
Deng, W.
Jung, H.
Keywords: Innate immunity
MICA
MULT1
Natural killer cells
RAE-1
ULBP
Issue Date: Mar-2013
Citation: Raulet, D.H., Gasser, S., Gowen, B.G., Deng, W., Jung, H. (2013-03). Regulation of ligands for the NKG2D activating receptor. Annual Review of Immunology 31 : 413-441. ScholarBank@NUS Repository. https://doi.org/10.1146/annurev-immunol-032712-095951
Abstract: NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves as a major recognition receptor for detection and elimination of transformed and infected cells and participates in the genesis of several inflammatory diseases. The ligands for NKG2D are self-proteins that are induced by pathways that are active in certain pathophysiological states. NKG2D ligands are regulated transcriptionally, at the level of mRNA and protein stability, and by cleavage from the cell surface. In some cases, ligand induction can be attributed to pathways that are activated specifically in cancer cells or infected cells. We review the numerous pathways that have been implicated in the regulation of NKG2D ligands, discuss the pathologic states in which those pathways are likely to act, and attempt to synthesize the findings into general schemes of NKG2D ligand regulation in NK cell responses to cancer and infection. © Copyright 2013 by Annual Reviews. All rights reserved.
Source Title: Annual Review of Immunology
URI: http://scholarbank.nus.edu.sg/handle/10635/125875
ISSN: 07320582
DOI: 10.1146/annurev-immunol-032712-095951
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