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Title: Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity
Authors: Mazzone, S.B.
Lim, L.H.K. 
Wagner, E.M.
Mori, N.
Canning, B.J.
Keywords: Bronchoconstriction
Intravital microscopy
Particle clearance
Tracheobronchial vasculature
Issue Date: Nov-2010
Source: Mazzone, S.B., Lim, L.H.K., Wagner, E.M., Mori, N., Canning, B.J. (2010-11). Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity. Journal of Applied Physiology 109 (5) : 1292-1300. ScholarBank@NUS Repository.
Abstract: The airways contain a dense subepithelial microvascular plexus that is involved in the supply and clearance of substances to and from the airway wall. We set out to test the hypothesis that airway smooth muscle reactivity to bronchoconstricting agents may be dependent on airway mucosal blood flow. Immunohistochemical staining identified vasoconstrictor and vasodilator nerve fibers associated with subepithelial blood vessels in the guinea pig airways. Intravital microscopy of the tracheal mucosal microvasculature in anesthetized guinea pigs revealed that blockade of α-adrenergic receptors increased baseline arteriole diameter by ∼40%, whereas the α-adrenergic receptor agonist phenylephrine produced a modest (5%) vasoconstriction in excess of the baseline tone. In subsequent in vivo experiments, tracheal contractions evoked by topically applied histamine were significantly reduced (P
Source Title: Journal of Applied Physiology
ISSN: 87507587
DOI: 10.1152/japplphysiol.00632.2010
Appears in Collections:Staff Publications

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