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Title: Intranuclear inclusions in epithelial cells of benign proliferative breast lesions
Authors: Harada, O.
Hoe, R.
Lin, J.
Thike, A.A.
Jara-Lazaro, A.R.
Petersson, F. 
Tan, P.H.
Issue Date: Sep-2011
Source: Harada, O., Hoe, R., Lin, J., Thike, A.A., Jara-Lazaro, A.R., Petersson, F., Tan, P.H. (2011-09). Intranuclear inclusions in epithelial cells of benign proliferative breast lesions. Journal of Clinical Pathology 64 (9) : 776-780. ScholarBank@NUS Repository.
Abstract: Aim: To document and clarify the nature of intranuclear inclusions of luminal epithelium in benign proliferative breast lesions. Methods and results: Five benign breast lesions were selected which showed intranuclear inclusions within epithelial cells on light microscopy. Following confirmation of their luminal epithelial (non-myoepithelial) localisation by immunohistochemistry, ultrastructural examination was performed with the following observations: (1) presence of deep nuclear indentations occasionally verging on nuclear inclusions; (2) inclusions with features of helioid bodies; and (3) a morphological spectrum of helioid bodies and their focal coexistence. Conclusion: Intranuclear inclusions of breast epithelium are likely of cytoplasmic origin. Helioid bodies may be formed by a stepwise process, the nature of which needs further study.
Source Title: Journal of Clinical Pathology
ISSN: 00219746
DOI: 10.1136/jclinpath-2011-200094
Appears in Collections:Staff Publications

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