Please use this identifier to cite or link to this item: https://doi.org/10.1128/JCM.00211-11
Title: Comparison of two nucleic acid amplification assays, the Xpert MTB/RIF assay and the amplified mycobacterium tuberculosis direct assay, for detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens
Authors: Teo, J.
Jureen, R. 
Chiang, D.
Chan, D.
Lin, R.
Issue Date: Oct-2011
Citation: Teo, J., Jureen, R., Chiang, D., Chan, D., Lin, R. (2011-10). Comparison of two nucleic acid amplification assays, the Xpert MTB/RIF assay and the amplified mycobacterium tuberculosis direct assay, for detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens. Journal of Clinical Microbiology 49 (10) : 3659-3662. ScholarBank@NUS Repository. https://doi.org/10.1128/JCM.00211-11
Abstract: We compared the performance of the Xpert MTB/RIF assay, a new real-time tuberculosis (TB) PCR test, with that of the Amplified Mycobacterium Tuberculosis Direct (MTD) assay using 162 respiratory and nonrespiratory specimens. Based on culture as the gold standard, the overall sensitivity and specificity for all sample types for the Xpert MTB/RIF assay were 90.9 and 89%, respectively, while for the MTD assay, the overall sensitivity and specificity were 97.3 and 87.1%, respectively. A higher proportion of total equivocal results were obtained for the MTD assay, at 10.5% (17/162), while the Xpert MTB/RIF assay generated 5.5% (9/162) of invalid reads. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Source Title: Journal of Clinical Microbiology
URI: http://scholarbank.nus.edu.sg/handle/10635/125624
ISSN: 00951137
DOI: 10.1128/JCM.00211-11
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