Please use this identifier to cite or link to this item: https://doi.org/10.1186/1748-717X-6-4
Title: The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer
Authors: Wang, X.
Xiong, X.-P.
Lu, J. 
Zhu, G.-P.
He, S.-Q.
Hu, C.-S.
Ying, H.-M.
Issue Date: 12-Jan-2011
Source: Wang, X., Xiong, X.-P., Lu, J., Zhu, G.-P., He, S.-Q., Hu, C.-S., Ying, H.-M. (2011-01-12). The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer. Radiation Oncology 6 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1748-717X-6-4
Abstract: Background: High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo.Methods: 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups: the normal control group, the single fraction with 18 Gy group, the two subfractions with 30 min interval group, the seven subfractions with 5 min interval group, the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency, the tumor growth delay and the mice survival time were analyzed.Results: The tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy (P < 0.05). The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P < 0.05). There was no significant difference between groups with same delivery time (P > 0.05). Compared to the group with single fraction of 18 Gy, the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min.Conclusions: The prolonged delivery time with same radiation dose shorten the tumor growth delay and survival time in the mice implanted with Lewis lung cancer. The anti-tumor effect decreased with elongation of the total interfractional time. © 2011 Wang et al; licensee BioMed Central Ltd.
Source Title: Radiation Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/125465
ISSN: 1748717X
DOI: 10.1186/1748-717X-6-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Jan 8, 2018

WEB OF SCIENCETM
Citations

13
checked on Jan 8, 2018

Page view(s)

10
checked on Jan 15, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.