Please use this identifier to cite or link to this item: https://doi.org/10.1210/en.2012-1258
Title: Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression
Authors: Huang, C.-C.J.
Shih, M.-C.M. 
Hsu, N.-C.
Chien, Y.
Chung, B.-C.
Issue Date: 1-Oct-2012
Citation: Huang, C.-C.J., Shih, M.-C.M., Hsu, N.-C., Chien, Y., Chung, B.-C. (2012-10-01). Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology 153 (10) : 4749-4756. ScholarBank@NUS Repository. https://doi.org/10.1210/en.2012-1258
Abstract: During pregnancy, fetal glucocorticoid is derived from both maternal supply and fetal secretion. We have created mice with a disruption of the Cyp11a1 gene resulting in loss of fetal steroid secretion but preserving the maternal supply. Cyp11a1 null embryos have appreciable although lower amounts of circulating corticosterone, the major mouse glucocorticoid, suggesting that transplacental corticosterone is a major source of corticosterone in fetal circulation. These embryos thus provide a means to examine the effect of fetal glucocorticoids. The adrenal in Cyp11a1 null embryos was disorganized with abnormal mitochondria and oil accumulation. The adrenal medullary cells did not express phenylethanolamine N-methyltransferase and synthesized no epinephrine. Cyp11a1 null embryos had decreased diencephalon Hsd11b1, increased diencephalon Crh, and increased pituitary Pomc expression, leading to higher adrenocorticotropin level in the plasma. These data indicate blunted feedback suppression despite reasonable amounts of circulating corticosterone. Thus, the corticosterone synthesized in situ by the fetus is required for negative feedback suppression of the hypothalamus-pituitary-adrenal axis and for catecholamine synthesis in adrenal medulla. Copyright © 2012 by The Endocrine Society.
Source Title: Endocrinology
URI: http://scholarbank.nus.edu.sg/handle/10635/124777
ISSN: 00137227
DOI: 10.1210/en.2012-1258
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