ENANTIOSELECTIVE ALLYLATION AND VINYLATION OF CARBONYLS, IMINES AND ALKENES

Abstract

THE CATALYTIC ALLYLATION AND VINYLATION HAVE BEEN DEVELOPED INTO ONE OF THE POWERFUL TOOL FOR C-C BOND FORMING REACTION. THE THESIS DESCRIBED MY EFFORTS DURING MY PH.D. RESEARCH FOR CHIRAL LEWIS BASE, CO-CATALYZED ENANTIOSELECTIVE ALLYLATION AND VINYLATION REACTIONS THAT RESULT IN THE FORMATION OF MANY BIOLOGICALLY AND PHARMACEUTICALLY IMPORTANT INTERMEDIATES. THE EFFICIENCY, SELECTIVITY, AND OPERATIONAL SIMPLICITY OF THE TRANSFORMATIONS AND THE BROAD RANGE OF ELECTROPHILES ARE EXPECTED TO RENDER THIS METHODOLOGY IMPORTANT FOR SYNTHESIS OF CHIRAL ALLYLIC AND HOMOALLYLIC ALCOHOLS, AMINES WHICH ARE USEFUL IN CHEMISTRY, BIOLOGY AND MEDICINE IN THE FUTURE.