Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/122590
Title: PREPARATION AND EVALUATION OF A 3D LIVER TUMOR SPHEROID MODEL VIA THE USE OF A COMPOSITE COLLAGEN AND POLYMER HYDROGEL
Authors: MARTIN NURMIK
Keywords: Three-dimensional tumor model, composite hydrogel, HepG2, ‘ABA’ triblock copolymers, tumor spheroids, poly(ethylene glycol)
Issue Date: 12-Feb-2016
Citation: MARTIN NURMIK (2016-02-12). PREPARATION AND EVALUATION OF A 3D LIVER TUMOR SPHEROID MODEL VIA THE USE OF A COMPOSITE COLLAGEN AND POLYMER HYDROGEL. ScholarBank@NUS Repository.
Abstract: OVER THE PAST DECADE, THERE HAS BEEN AN EXPONENTIAL INCREASE IN BOTH THE NUMBER AND COMPLEXITY OF VARIOUS ANTI-TUMOR THERAPIES AND DRUGS. THESE DEVELOPMENTS, IN TURN, HAVE NECESSITATED THE DEVELOPMENT OF A THREE-DIMENSIONAL TUMOR TISSUE MODEL THAT COULD ADEQUATELY REPLICATE THE IN-VIVO TUMOR ENVIRONMENT. WHILE VARIOUS DIFFERENT MODELS HAVE BEEN SUGGESTED, THE VAST MAJORITY OF THEM RELY ON THE USE OF NATURAL BIOMATERIALS, SUCH AS TYPE I COLLAGEN AND MATRIGEL, TO PROVIDE AN ENVIRONMENT THAT CAN MIMIC CELL-ECM INTERACTIONS. HOWEVER, WEAKNESSES SUCH AS HIGH COST AND MECHANICAL INFLEXIBILITY, REMAIN LARGE STUMBLING BLOCKS. USING HYDROGELS FORMED OUT OF BOTH PEG-BASED TRIBLOCK CO-POLYMERS (POLY(MTC-VITE)1.25-PEG10K-POLY(MTC-VITE1.25), POLY(MTC-VITE)2.5-PEG10K-POLY(MTC-VITE)2.5 AND POLY(MTC-OBN)8.5 -PEG8K-POLY(MTC-OBN)8.5) AND TYPE I COLLAGEN, A NUMBER OF THREE-DIMENSION (3D) MATRICES HAVE BEEN PREPARED FOR TUMOR SPHEROID GROWTH. THE 3D MATRICES HAVE BEEN CHARACTERIZED FOR HYDROGEL CLARITY,
URI: http://scholarbank.nus.edu.sg/handle/10635/122590
Appears in Collections:Master's Theses (Open)

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