Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121732
Title: RHINITIS IN THE FIRST 18 MONTHS OF LIFE: EPIDEMIOLOGY AND RELATIONSHIP WITH CO-MORBIDITIES AND RESPIRATORY VIRUSES
Authors: ANTONY HARDJOJO
Keywords: birth cohort, rhinitis, respiratory virus, quality of life, infants, atopy
Issue Date: 27-Mar-2015
Source: ANTONY HARDJOJO (2015-03-27). RHINITIS IN THE FIRST 18 MONTHS OF LIFE: EPIDEMIOLOGY AND RELATIONSHIP WITH CO-MORBIDITIES AND RESPIRATORY VIRUSES. ScholarBank@NUS Repository.
Abstract: This thesis aimed to evaluate the epidemiology of rhinitis in first 18 months of life, and to explore the role of respiratory viruses in its pathogenesis. Subjects (n=738) from the GUSTO birth cohort were followed-up from birth at 7 scheduled visits till 18th months old. The prevalence of rhinitis of at least 2 week duration was 32.1%. A subset of prolonged/recurrent rhinitis defined as rhinitis of at least 4 weeks in the first 18 months was present in 18.8%. Prolonged/recurrent rhinitis was associated with atopic co-morbidities (eczema and wheeze) and a parental history of allergies. It was also found to cause sleeping and feeding disturbances in majority of subjects. Nasal swabs collected within a month following prolonged/recurrent rhinitis episodes had significantly higher virus detection rate than at the 7 scheduled timepoints, suggesting a possible role of respiratory viruses in prolonged/recurrent rhinitis symptomatology.
URI: http://scholarbank.nus.edu.sg/handle/10635/121732
Appears in Collections:Ph.D Theses (Open)

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