Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121702
Title: NOVEL ANTICOAGULANTS FROM HEMATOPHAGOUS ANIMALS
Authors: IYER JANAKI KRISHNAMOORTHY
Keywords: thrombin, thrombin inhibitor, anticoagulant, Amblyomma variegatum, Dermacentor reticulatus, online assay
Issue Date: 20-Aug-2015
Citation: IYER JANAKI KRISHNAMOORTHY (2015-08-20). NOVEL ANTICOAGULANTS FROM HEMATOPHAGOUS ANIMALS. ScholarBank@NUS Repository.
Abstract: THROMBIN AND FACTOR XA PLAY PIVOTAL ROLES IN HAEMOSTASIS, AND THEIR INHIBITORS COMPRISE A SIGNIFICANT FRACTION OF ANTITHROMBOTIC DRUGS. HEMATOPHAGOUS ANIMALS HAVE EVOLVED MOLECULES THAT CONTROL HOST HAEMOSTASIS TO ENSURE A SUCCESSFUL FEEDING. I ADOPTED THREE APPROACHES TO IDENTIFY NOVEL ANTICOAGULANTS: A MICROFLUIDIC CHIP-BASED BIOASSAY COUPLED TO MASS SPECTROMETRY; (2) QUANTITATIVE TRANSCRIPTOMIC AND PROTEOMIC PROFILING OF THE SALIVARY GLAND EXTRACTS OF MALE AND FEMALE DERMACENTOR RETICULATUS; AND SYSTEMATIC ANALYSIS OF EXISTING SEQUENCES. I HAVE IDENTIFIED TWO NOVEL THROMBIN INHIBITORS AND STUDIED THEIR STRUCTURE ACTIVITY RELATIONSHIPS AND DEMONSTRATED ITS IN VIVO EFFICACY IN A MURINE MODEL. I HAVE ALSO DESCRIBED A NEW FAMILY OF THROMBIN INHIBITORS FROM IXODID TICKS, WHICH POSSESS AFFINITIES IN THE NANOMOLAR TO FEMTOMOLAR RANGE, AND SELECTIVELY INHIBIT THROMBIN. I HAVE IDENTIFIED A NOVEL FXA INHIBITOR AND DEVELOPED AN AFFINITY CHROMATOGRAPHY FOR THE PURIFICATION OF THIS FXA INHIBIT
URI: http://scholarbank.nus.edu.sg/handle/10635/121702
Appears in Collections:Ph.D Theses (Open)

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