Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121356
Title: INSIGHTS INTO ANTIBODY AND T-CELL MEDIATED IMMUNITY TO INFLUENZA FROM POPULATION-BASED COHORT STUDIES
Authors: HSU JUNG PU
Keywords: Influenza, antibody,T-cell, population-based, cohort, vaccine
Issue Date: 23-Jul-2015
Citation: HSU JUNG PU (2015-07-23). INSIGHTS INTO ANTIBODY AND T-CELL MEDIATED IMMUNITY TO INFLUENZA FROM POPULATION-BASED COHORT STUDIES. ScholarBank@NUS Repository.
Abstract: INFLUENZA VACCINES INDUCE VIRUS-SPECIFIC ANTIBODIES TO PROTECT AGAINST INFECTION. HOWEVER, THE DECLINE OF ANTIBODY OVERTIME INCREASES THE NEED FOR DEVELOPING VACCINE THAT ELICIT CYTOTOXIC T-CELL IMMUNITY. THE OBJECTIVES ARE TO INVESTIGATE: 1)THE TRAJECTORY OF ANTIBODY DECLINE FOLLOWING SEROCONVERSION TO A(H1H1)PDM09; 2)THE ROLE OF PRE-EXISTING T-CELL IMMUNITY TO A/SINGAPORE/CDC204/2012(H3N2) IN PROTECTING AGAINST SUBSEQUENT INFLUENZA INFECTIONS. IN CHAPTER 2, THE DECLINE WAS ASSESSED WITH A COHORT WHO PREVIOUSLY SEROCONVERTED TO A(H1N1)PDM09 (N=67). PROPORTION OF SERO-POSITIVITY (HI=40) DECREASED SIGNIFICANTLY FROM 71% TO 25% AFTER SIX MONTHS, AND IS MORE SIGNIFICANT IN ELDERLY. IN CHAPTER 3, THE PROTECTIVE EFFECT OF PRE-EXISTING T-CELL IMMUNITY TOWARDS A/SINGAPORE/CDC204/2012(H3N2) ON SUBSEQUENT INFLUENZA INFECTIONS WAS ASSESSED WITH A COMMUNITY COHORT (N=507). A SIGNIFICANT PROTECTIVE EFFECT WAS OBSERVED FOR BOTH SYMPTOMATIC AND ASYMPTOMTIC INFECTIONS; AND WAS MORE EVIDENT IN P
URI: http://scholarbank.nus.edu.sg/handle/10635/121356
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
HsuJP.pdf1.59 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

140
checked on Mar 22, 2019

Download(s)

22
checked on Mar 22, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.