Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates

Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.00433-09

Title:	Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates
Authors:	Yu, M.H. Sun, Y.-J. Wong, S.-Y. Lee, A.S.G.
Issue Date:	2009
Citation:	Yu, M.H., Sun, Y.-J., Wong, S.-Y., Lee, A.S.G. (2009). Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates. Antimicrobial Agents and Chemotherapy 53 (9) : 4010-4012. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.00433-09
Abstract:	Screening of 127 isoniazid (INH)-resistant Mycobacterium tuberculosis isolates from Singapore for mutations within the dfrA and inhA genes revealed mutations in 0 and 5 (3.9%) isolates respectively, implying that mutations in dfrA do not contribute to the detection of INH-resistant M. tuberculosis and that mutations within inhA are rare. Thirty-seven (29%) of the 127 isolates had no mutations in any of the genes implicated in INH resistance (katG, kasA, and ndh; inhA and ahpC promoters), suggesting that there are new INH targets yet to be discovered. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Source Title:	Antimicrobial Agents and Chemotherapy
URI:	http://scholarbank.nus.edu.sg/handle/10635/120844
ISSN:	00664804
DOI:	10.1128/AAC.00433-09
Appears in Collections:	Staff Publications

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