Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120727
Title: Capturing the sublimity of a free radical gas
Authors: Leong, S.-K. 
Keywords: Cochlea
Endocrine and immune organs
NADPH-d
Neurodestructive
Neuroprotective
Nitric oxide
NOS
Nucleus dorsalis
Peroxynitrite
Red nucleus
Issue Date: 1999
Citation: Leong, S.-K. (1999). Capturing the sublimity of a free radical gas. Free Radical Research 31 (6) : 619-629. ScholarBank@NUS Repository.
Abstract: This paper reviews the work related to nitric oxide (NO) done by the author and his postgraduates and colleagues in the past 7 years in the National University of Singapore. Our work shows that (i) NADPH-d and NO synthase (NOS) are often but not always identical; (ii) NO (as indicated by NADPH-d histochemistry and NOS immunohistochemistry) is generated in some endocrine (thyroid, parathyroid and ultimobranchial glands) and immune (thymus and bursa of Fabricius) organs and the cochlea. It is noted from the above studies that NO could possibly regulate blood flow through the various organs via its presence in the vascular endothelial cells and also via nitrergic neurons innervating the blood vessels. It could also regulate the activity of the secretary cells of these organs by being present in them, as well as acting through nitrergic neurons closely related to them. The paper also examines the Janus-faced nature of NO as a neuroprotective and neurodestructive agent, and the apparent noninvolvement of peroxynitrite and inducible NOS in neuronal death occurring in the red nucleus and nucleus dorsalis after spinal cord hemisection.
Source Title: Free Radical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/120727
ISSN: 10715762
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

26
checked on Sep 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.