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|Title:||Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation|
Nanjunda Swamy, S.
Ananda Kumar, C.S.
Sunil Kumar, Y.C.
|Citation:||Thimmegowda, N.R., Nanjunda Swamy, S., Ananda Kumar, C.S., Sunil Kumar, Y.C., Chandrappa, S., Yip, G.W., Rangappa, K.S. (2008-01-01). Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorganic and Medicinal Chemistry Letters 18 (1) : 432-435. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.08.078|
|Abstract:||A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor. © 2007 Elsevier Ltd. All rights reserved.|
|Source Title:||Bioorganic and Medicinal Chemistry Letters|
|Appears in Collections:||Staff Publications|
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