Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2007.08.078
Title: Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation
Authors: Thimmegowda, N.R.
Nanjunda Swamy, S.
Ananda Kumar, C.S.
Sunil Kumar, Y.C.
Chandrappa, S.
Yip, G.W. 
Rangappa, K.S.
Keywords: Cell proliferation
MDA-MB-231
Trisubstituted benzimidazole
Issue Date: 1-Jan-2008
Citation: Thimmegowda, N.R., Nanjunda Swamy, S., Ananda Kumar, C.S., Sunil Kumar, Y.C., Chandrappa, S., Yip, G.W., Rangappa, K.S. (2008-01-01). Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorganic and Medicinal Chemistry Letters 18 (1) : 432-435. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.08.078
Abstract: A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Bioorganic and Medicinal Chemistry Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/120673
ISSN: 0960894X
DOI: 10.1016/j.bmcl.2007.08.078
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