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|Title:||Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation|
|Authors:||Ananda Kumar, C.S.|
Nanjunda Swamy, S.
Benaka Prasad, S.B.
|Citation:||Ananda Kumar, C.S., Nanjunda Swamy, S., Thimmegowda, N.R., Benaka Prasad, S.B., Yip, G.W., Rangappa, K.S. (2007). Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Medicinal Chemistry Research 16 (4) : 179-187. ScholarBank@NUS Repository. https://doi.org/10.1007/s00044-007-9022-y|
|Abstract:||A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity. © Birkhäuser 2007.|
|Source Title:||Medicinal Chemistry Research|
|Appears in Collections:||Staff Publications|
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