Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00044-007-9022-y
Title: Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation
Authors: Ananda Kumar, C.S.
Nanjunda Swamy, S.
Thimmegowda, N.R.
Benaka Prasad, S.B.
Yip, G.W. 
Rangappa, K.S.
Keywords: 1-benzhydryl-piperazine derivatives
Cell proliferation
MDA-MB-231
Sulfonyl chlorides
Issue Date: 2007
Citation: Ananda Kumar, C.S., Nanjunda Swamy, S., Thimmegowda, N.R., Benaka Prasad, S.B., Yip, G.W., Rangappa, K.S. (2007). Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Medicinal Chemistry Research 16 (4) : 179-187. ScholarBank@NUS Repository. https://doi.org/10.1007/s00044-007-9022-y
Abstract: A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity. © Birkhäuser 2007.
Source Title: Medicinal Chemistry Research
URI: http://scholarbank.nus.edu.sg/handle/10635/120667
ISSN: 10542523
DOI: 10.1007/s00044-007-9022-y
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

31
checked on Aug 21, 2018

WEB OF SCIENCETM
Citations

26
checked on Aug 21, 2018

Page view(s)

36
checked on Aug 2, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.