Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120586
Title: MULTIDRUG RESISTANT GRAM NEGATIVE ORGANISMS: EPIDEMIOLOGY AND OUTCOMES IN THE ICU
Authors: ANUPAMA VASUDEVAN
Keywords: Multidrug-resistant, Gram-negative bacteria, ICU, mortality, inappropriate antibiotics, prediction tool
Issue Date: 8-Aug-2014
Citation: ANUPAMA VASUDEVAN (2014-08-08). MULTIDRUG RESISTANT GRAM NEGATIVE ORGANISMS: EPIDEMIOLOGY AND OUTCOMES IN THE ICU. ScholarBank@NUS Repository.
Abstract: With the increasing global threat of antimicrobial resistance especially among Gram-negative bacteria (GNB), a prospective observational study(Aug?07-Dec?11) including 2949 patients who had stayed for more than 24-hours in the intensive care unit (ICU) was conducted at the National University Hospital. A prediction tool for nosocomial ICU acquired multidrug-resistant (MDR)-GNB infection was constructed using independent risk factors identified and was validated. The effects of initial inappropriate antibiotics on mortality along with resistance selection from empiric broad spectrum therapy were also quantified. Economic impact was evaluated using a propensity score approach. We believe that our validated prediction tool will help target empirical antibiotics for high risk ICU patients; for the remainder, a 72-hour window period was identified for antibiotic adjustment to improve survival while minimizing collateral damage among patients with GNB infection. This will help safely reduce the problem of antimicrobial resistance amongst critically ill patients.
URI: http://scholarbank.nus.edu.sg/handle/10635/120586
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3_Summary TOC.pdf255.38 kBAdobe PDF

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4_article 1_Costs_AV_2015.pdf457 kBAdobe PDF

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5_article 2_Prediction tool_AV_2014.pdf791.23 kBAdobe PDF

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6_article 3_Mortality antibiotics_Published article_final.pdf664.54 kBAdobe PDF

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7_article 4_Preventive medicine_2013.pdf126.03 kBAdobe PDF

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8_article 5_Asia Pacific bitech news_page 22_27.pdf358.04 kBAdobe PDF

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9_Body.pdf1.76 MBAdobe PDF

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10_Annex 1_CRF.pdf660.77 kBAdobe PDF

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