Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119651
Title: A STUDY OF SAMD9 AND PSMB9 AS POTENTIAL DOWNSTREAM MOLECULES OF HS6ST3 IN HUMAN BREAST CANCER
Authors: LUM YICK LIANG
Keywords: HS6ST3, SAMD9, PSMB9, breast cancer, glycosaminoglycan, heparan sulfate
Issue Date: 23-Jan-2015
Citation: LUM YICK LIANG (2015-01-23). A STUDY OF SAMD9 AND PSMB9 AS POTENTIAL DOWNSTREAM MOLECULES OF HS6ST3 IN HUMAN BREAST CANCER. ScholarBank@NUS Repository.
Abstract: BREAST CANCER IS THE MOST COMMONLY DIAGNOSED CANCER AMONG FEMALE. DESPITE ADVANCES IN CANCER TREATMENT, BREAST CANCER HAS CONTRIBUTED TO MOST OF FEMALE CANCER DEATH NOWADAYS. HENCE SEARCHING FOR BIOMARKER AND THERAPEUTIC TARGET REMAINED AS TOP PRIORITY IN BREAST CANCER RESEARCH. HEPARAN SULFATE 6-O SULFOTRANSFERASE 3 (HS6ST3) IS A POTENTIAL TARGET IN THIS REGARD. HS6ST3 IS A KEY REGULATOR OF BREAST CANCER PHENOTYPES. SILENCING OF HS6ST3 WAS FOUND TO SUPPRESS BREAST CANCER GROWTH, INVASION AND MIGRATION WHILE INDUCING APOPTOSIS. UNDERSTANDING OF UNDERLYING MECHANISM THAT LEAD TO PHENOTYPIC CHANGES WOULD BE USEFUL TO EXPLORE ALTERNATE ROUTE THAT CONTRIBUTE TO BREAST CANCER PROGRESSION. THE AIM OF THIS STUDY WAS TO IDENTIFY POTENTIAL DOWNSTREAM MOLECULES OF HS6ST3 IN HUMAN BREAST CANCER. DNA MICROARRAY WAS USED IN HS6ST3-SILENCED MCF7 BREAST CANCER CELL LINE TO ASSESS GENOME WIDE EXPRESSION CHANGES. ANALYZED DATA SHOWED THAT THERE WERE 220 UPREGULATED GENES AND 159 DOWNREGULATED GENES WIT
URI: http://scholarbank.nus.edu.sg/handle/10635/119651
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LumYL Master Thesis.pdf1.64 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

123
checked on Nov 16, 2018

Download(s)

57
checked on Nov 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.