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https://scholarbank.nus.edu.sg/handle/10635/119619
Title: | GLOBAL DISCOVERY OF DYSREGULATED PROTEIN EXPRESSION AND PHOSPHORYLATION NETWORKS IDENTIFIED LEO1 AS A KEY TARGET OF PRL-3 PHOSPHATASE IN LEUKEMOGENESIS | Authors: | CHONG SHU YUN, PHYLLIS | Keywords: | phosphoproteomics, PRL-3, PAF complex, Leo1, AML | Issue Date: | 1-Aug-2014 | Citation: | CHONG SHU YUN, PHYLLIS (2014-08-01). GLOBAL DISCOVERY OF DYSREGULATED PROTEIN EXPRESSION AND PHOSPHORYLATION NETWORKS IDENTIFIED LEO1 AS A KEY TARGET OF PRL-3 PHOSPHATASE IN LEUKEMOGENESIS. ScholarBank@NUS Repository. | Abstract: | PRL-3, an oncogenic dual-specificity phosphatase, is over-expressed in 50% of AML and associated with poor survival. We found that stable expression of PRL-3 in the cytokine-dependent TF-1 AML cells confers cytokine-independent growth, induces colony-forming ability in methylcellulose media and tumorigenesis in vivo. However, how PRL-3 mediates these functions in AML is unknown. To systematically characterize novel substrates of PRL-3 in leukemia, unbiased large-scale proteomics and phosphoproteomics analyses were performed between the parental TF-1 cells and their malignant PRL-3 transfectant counterparts to discover critical differences in signaling networks. | URI: | http://scholarbank.nus.edu.sg/handle/10635/119619 |
Appears in Collections: | Ph.D Theses (Open) |
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Thesis FINAL (UPLOAD).pdf | 8.06 MB | Adobe PDF | OPEN | None | View/Download |
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