Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119452
Title: CHARACTERIZING THERAPEUTICALLY RESISTANT HUMAN GLIOBLASTOMA CELLS
Authors: LOW YIN YEE SHARON (LIU YINGYI)
Keywords: glioblastoma, microRNA
Issue Date: 21-Aug-2014
Source: LOW YIN YEE SHARON (LIU YINGYI) (2014-08-21). CHARACTERIZING THERAPEUTICALLY RESISTANT HUMAN GLIOBLASTOMA CELLS. ScholarBank@NUS Repository.
Abstract: `GLIOBLASTOMA MULTIFORME? RETAINS ITS REPUTATION AS THE MOST COMMON AND DEVASTATING PRIMARY BRAIN TUMOUR AFFECTING ADULTS. THIS DISEASE?S THERAPEUTIC RESISTANCE FORTIFY IT AS ONE OF THE MOST CHALLENGING CANCERS TO MANAGE. DESPITE THE IMPLEMENTATION OF AGGRESSIVE TREATMENT WHICH CONSISTS OF MAXIMAL SAFE SURGICAL RESECTION, FOLLOWED BY CONCOMITANT CHEMOTHERAPY AND HIGH-DOSE RADIATION, THE OVERALL PROGNOSIS REMAINS ABYSMAL. TUMOUR RECURRENCE IS AN INEVITABLE EVENT. AT THIS STAGE, THE IDENTIFICATION OF SURVIVING CELLS RESPONSIBLE FOR TUMOUR RECURRENCE HAS YET TO BE CLINICALLY DETERMINED. BASED ON THESE OBSERVATIONS, WE HYPOTHESIZED THAT THERE ARE DIFFERENT CELL POPULATIONS WITHIN GLIOBLASTOMA THAT POSSESS INNATE RESISTANCE MECHANISMS AGAINST CHEMO-RADIATION INDUCED CELL DEATH, ALLOWING THEM TO SURVIVE AND INITIATE TUMOUR RECURRENCE.
URI: http://scholarbank.nus.edu.sg/handle/10635/119452
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PhD Thesis_LYYS.pdf4.07 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

76
checked on Feb 15, 2018

Download(s)

20
checked on Feb 15, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.