Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119391
Title: GENETIC ANALYSIS AND FUNCTIONAL CHARACTERIZATIONS OF SEMAPHORIN 5A AND PLEXIN-B3 IN HUMAN GLIOMAS
Authors: FATHIMA RIFKHANA SHAH JAHAN
Keywords: Axon guidance, semaphorin, semaphorin 5A, plexin-B3, glioma, astrocytoma,
Issue Date: 22-Aug-2014
Source: FATHIMA RIFKHANA SHAH JAHAN (2014-08-22). GENETIC ANALYSIS AND FUNCTIONAL CHARACTERIZATIONS OF SEMAPHORIN 5A AND PLEXIN-B3 IN HUMAN GLIOMAS. ScholarBank@NUS Repository.
Abstract: SEMAPHORINS AND THEIR RECEPTORS PLEXINS ARE LARGE FAMILY OF MOLECULES KNOWN TO CONTROL AXON GUIDANCE FUNCTIONS. ACCUMULATING EVIDENCE SUGGESTS THAT THEY ALSO PLAY IMPORTANT ROLE IN A PLETHORA OF BIOLOGICAL PROCESSES RANGING FROM CELL MIGRATION, ANGIOGENESIS, IMMUNE RESPONSES TO CANCER PROGRESSION. WE HAVE RECENTLY DEMONSTRATED THE EFFECTS OF SEMAPHORIN 5A (SEMA5A) IN INHIBITING MIGRATION, INVASION, AND PROLIFERATION IN HUMAN ASTROCYTOMAS THROUGH ITS RECEPTOR PLEXIN-B3. ANALYSIS OF HUMAN ASTROCYTOMA SPECIMENS FROM LOW TO HIGH GRADES REVEALED A MARKED DECLINE IN SEMA5A PROTEIN LEVELS. RECONSTITUTION OF SEMA5A EXPRESSION IN ADVANCED GRADE OF GLIOBLASTOMAS SUCCESSFULLY COUNTERACTS INVASION AND PROLIFERATION OF CANCER CELLS. WE THEREFORE HYPOTHESIZED THAT SEMA5A AND PLEXIN-B3 SUBSERVE TUMOR SUPPRESSOR FUNCTIONS, WHICH ARE COMPROMISED IN GLIOBLASTOMAS DUE TO A DOWNREGULATION OF SEMA5A, HENCE CONTRIBUTING TO HIGH INFILTRATION AND MALIGNANCY. IN THIS STUDY, WE INVESTIGATED THE MECHANISMS UNDER
URI: http://scholarbank.nus.edu.sg/handle/10635/119391
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ShahjahanFR.pdf5.79 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

92
checked on Jan 18, 2018

Download(s)

11
checked on Jan 18, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.