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|Title:||Optimized analytical method for cyclosporin A by high-performance liquid chromatography-electrospray ionization mass spectrometry|
|Authors:||Zhou, L. |
|Citation:||Zhou, L., Tan, D., Lam, K.-W., Theng, J., Lim, L., Liu, Y.-P. (2001). Optimized analytical method for cyclosporin A by high-performance liquid chromatography-electrospray ionization mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 754 (1) : 201-207. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-4347(00)00608-3|
|Abstract:||The Micromass Platform LCZ mass detector parameters were optimized for simultaneous recording of the protonated (CsA∼H+), sodium adduct (CsA∼Na+) and potassium adduct (CsA∼K+) of cyclosporin A eluted from a Symmetry Shield RP8 column. The optimized procedure allows a precise analysis of CsA in whole blood or serum without removal of salts prior to analysis. The ratio of the three forms of CsA varied depending on the assay condition and the types of specimens being analyzed. The summation of three ionic forms of CsA detected by LC-ESI-MS is a reliable and simple method to assess CsA concentration in the blood. © 2001 Elsevier Science B.V.|
|Source Title:||Journal of Chromatography B: Biomedical Sciences and Applications|
|Appears in Collections:||Staff Publications|
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